News Archives ⋆ Phytocopeia

Study ties poor sleep to reduced memory performance in older adults

A new study has found that variability in night-to-night sleep time and reduced sleep quality adversely affect the ability of older adults to recall information about past events. The study also found unexpected racial differences in the type of sleep patterns tied to lower memory performance across both younger and older African American research participants.

Antioxidant puts up fight, but loses battle against protein linked to Alzheimer’s disease

New research may explain why an antioxidant that protects the brain is also associated with deterioration in areas susceptible to Alzheimer’s disease. The antioxidant, superoxide dismutase or SOD1, improves cognition, but a research team found SOD1’s protective benefits dramatically weaken when levels of tau proteins — a hallmark of Alzheimer’s disease — increase.

Potential new therapeutic target for Alzheimer’s disease

Apolipoproten E (apoeE) is a major genetic risk factor for the development of Alzheimer’s disease, yet it tends to be understudied as a potential druggable target for the mind-robbing neurodegenerative disease. Now a research team reports that a novel apoE antagonist blocks apoE interaction with N-terminal amyloid precursor protein (APP) and reduces hallmark Alzheimer’s-associated pathologies.

Early life stress plus overexpressed FKBP5 protein increases anxiety behavior

A new preclinical study finds that anxiety-like behavior increases when early life adversity combines with high levels of FKBP5 — a protein capable of modifying hormonal stress response. Moreover, the researchers demonstrate this genetic-early life stress interaction amplifies anxiety by selectively altering signaling of the enzyme AKT in the dorsal hippocampus, a portion of the brain primarily responsible for cognitive functions like learning and memory.