News Archives ⋆ Phytocopeia

Potential new treatment target for Alzheimer’s disease

A new study not only sheds light on how the APOE4 gene may cause some of the pathologies associated with Alzheimer’s disease, but also suggests a new treatment target that might help people who carry the APOE4 gene in early and late stages of the disease. Researchers found that APOE4 is associated with the activation of an inflammatory protein that causes a breakdown in the blood-brain barrier which protects the brain.

New super-resolution technique allows for more detailed brain imaging

A new imaging technique has the potential to detect neurological disorders — such as Alzheimer’s disease — at their earliest stages, enabling physicians to diagnose and treat patients more quickly. Termed super-resolution, the imaging methodology combines position emission tomography (PET) with an external motion tracking device to create highly detailed images of the brain.

Largescale brain epigenetics study provides new insights into dementia

The team looked in different regions of the brain, which are affected in Alzheimer’s disease before looking for common changes across these cortical regions. They identified 220 sites in the genome, including 84 new genes, which showed different levels of DNA methylation in the cortex in individuals with more severe Alzheimer’s disease, which weren’t seen in the cerebellum.