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Why can some people weather the stress of social isolation better than others, and what implications does this have for their health? New research found that people who felt a strong sense of purpose in life were less lonely during the COVID-19 pandemic.

Scientists explore how protein and signaling pathways change in patients with Alzheimer’s disease. Their work creates a new model of disease progression, taking advantage of the heterogeneity that is inherent to human studies.

A new study not only sheds light on how the APOE4 gene may cause some of the pathologies associated with Alzheimer’s disease, but also suggests a new treatment target that might help people who carry the APOE4 gene in early and late stages of the disease. Researchers found that APOE4 is associated with the activation of an inflammatory protein that causes a breakdown in the blood-brain barrier which protects the brain.